How Mesp1 makes a move

How Mesp1 makes a move

The transcription factors Mesp1 and Mesp2 have essential roles in the migration and specification of multipotent progenitor cells at the onset of cardiogenesis. Chiapparo et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201505082) identify common Mesp functions in fate specification and Mesp1-specific targets controlling the speed and direction of progenitor cell migration.

Viroid trafficking: a small RNA makes a big move.

RNA trafficking has broad implications in the systemic spread of infectious agents, plant defense, and the systemic regulation of gene expression. The mechanisms that regulate trafficking remain poorly understood. The non-coding, infectious viroid RNAs are emerging as highly tractable model systems for the investigation of the basic mechanisms of RNA trafficking. Recent studies on viroids have ...

From local to global: lipid emulsion (intralipid) makes a move.

I N clinical practice, lipid emulsion is used commonly as a component of parenteral nutrition. Lipid emulsion also is used as therapy for severe cardiotoxicity secondary to accidental overdose of local anesthetics, an effect that has been confirmed in animals and humans. Because patients with local anesthetic-induced cardiac arrest are considered to be less responsive for standard resuscitation...

How "you" makes meaning.

"You" is one of the most common words in the English language. Although it typically refers to the person addressed ("How are you?"), "you" is also used to make timeless statements about people in general ("You win some, you lose some."). Here, we demonstrate that this ubiquitous but understudied linguistic device, known as "generic-you," has important implications for how people derive meaning...

How Practice Makes Perfect